Hydrochloric Acid → HCID 22755625, compound

HRID 66143Notes

Reaction equation

HRID 66143 reaction equation
C(OC(=O)C[N:6]1[C:11]([C:12]([O:14]CC)=[O:13])=[CH:10][C:9](=[O:17])[C:8]2[CH:18]=[C:19]([O:24][CH2:25][C:26]([O:28]CC)=[O:27])[C:20](=[O:23])[CH:21]=[CH:22][C:7]1=2)C.Cl>>[O:17]=[C:9]1[CH:10]=[C:11]([C:12]([OH:14])=[O:13])[NH:6][C:7]2[CH:22]=[CH:21][C:20](=[O:23])[C:19]([O:24][CH2:25][C:26]([OH:28])=[O:27])=[CH:18][C:8]1=2

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 543234444,7-dihydro-4,7-dioxo-2-ethoxycarbonyl-6-[(2-ethoxy-2-oxoethyl)oxy]-1H-cyclohepta[b]pyridine-1-acetic acid ethyl ester

Product 1

HCID 22755625HCID 22755625, compound

Procedure

A mixture of 4,7-dihydro-4,7-dioxo-2-ethoxycarbonyl-6-[(2-ethoxy-2-oxoethyl)oxy]-1H-cyclohepta[b]pyridine-1-acetic acid ethyl ester (0.617 g, described in Example 15) and 19% hydrochloric acid (4.2 ml) is refluxed for 1 hr and cooled to room temperature. The precipitate is collected and washed with water, acetone and ether to obtain the title compound, mp > 270° C.

Workup

  1. temperatureis refluxed for 1 hr
  2. customThe precipitate is collected
  3. washwashed with water, acetone and ether

Sources & evidence

ORD record
ord-3e7aff66cd014058a6e40a2d197658b2
Source dataset
uspto-grants-1978_12
Patent number
US04130649

Reaction notes

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