反应详情

A mixture of 4,7-dihydro-4,7-dioxo-2-ethoxycarbonyl-6-[(2-ethoxy-2-oxoethyl)oxy]-1H-cyclohepta[b]pyridine-1-acetic acid ethyl ester (0.617 g, described in Example 15) and 19% hydrochloric acid (4.2 ml) is refluxed for 1 hr and cooled to room temperature. The precipitate is collected and washed with water, acetone and ether to obtain the title compound, mp > 270° C.

1. temperatureis refluxed for 1 hr
2. customThe precipitate is collected
3. washwashed with water, acetone and ether