Methane → 4,7-Dihydro-4,7-dioxo-6-propoxy-1H-cyclohepta[b]pyridine-2-carboxylic acid

HRID 66148Notes

Reaction equation

HRID 66148 reaction equation
C([O:3][C:4]([C:6]1[N:11](CCC)[C:10]2[CH:15]=[CH:16][C:17](=[O:24])[C:18]([O:20][CH2:21][CH2:22][CH3:23])=[CH:19][C:9]=2[C:8](=[O:25])[CH:7]=1)=[O:5])C.Cl.C>>[O:25]=[C:8]1[CH:7]=[C:6]([C:4]([OH:5])=[O:3])[NH:11][C:10]2[CH:15]=[CH:16][C:17](=[O:24])[C:18]([O:20][CH2:21][CH2:22][CH3:23])=[CH:19][C:9]1=2

Participants

4

Reactant 3

HCID 297MethaneHCID 313Hydrochloric AcidHCID 53707130HCID 53707130, compound

Product 1

HCID 227556674,7-Dihydro-4,7-dioxo-6-propoxy-1H-cyclohepta[b]pyridine-2-carboxylic acid

Procedure

A mixture of 4,7-dihydro-4,7-dioxo-6-propoxy-1-propyl-1H-cyclohepta[b]pyridine-2-carboxlic acid ethyl ester (3.8 g, described in Example 22) and 19% hydrochloric acid (113 ml) is refluxed for 30 minutes. Charcoal is added and the hot mixture is filtered. The filtrate is cooled to room temperature and the crystalline precipitate is collected and dried to obtain the title compound, mp > 250° C.

Workup

  1. temperatureis refluxed for 30 minutes
  2. filtrationthe hot mixture is filtered
  3. customthe crystalline precipitate is collected
  4. customdried

Sources & evidence

ORD record
ord-768ff5e905c442d292fe4bdf6acf1096
Source dataset
uspto-grants-1978_12
Patent number
US04130649

Reaction notes

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