反应详情

ethyl 2-methyl-7-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxylate (S3) 1.0 g (4.5 mmol) in 25 ml aq. LiOH solution (1 mol/L) was stirred for 48 hours at 70° C. The mixture was poured into the ice water, then acidified with 6 mol/L HCl to pH 1 to 2. The gray solid was collected by filtration, washed with water and dried in vacuum condition to give 0.64 g (74%) of the titled compound.

1. filtrationThe gray solid was collected by filtration
2. washwashed with water
3. customdried in vacuum condition