Triethylamine → 5-[6-(4-Methoxy-benzylamino)-pyridin-2-yl]-pent-4-ynoic acid butyl ester

HRID 662560Notes

Reaction equation

HRID 662560 reaction equation
[Br:1][c:2]1[cH:3][cH:4][cH:5][c:6]([NH:8][CH2:9][c:10]2[cH:11][cH:12][c:13]([O:16][CH3:17])[cH:14][cH:15]2)[n:7]1.[CH2:18]([CH2:19][CH2:20][CH3:21])[O:22][C:23]([CH2:24][CH2:25][C:26]#[CH:27])=[O:28].[CH3:29][CH2:30][N:31]([CH2:32][CH3:33])[CH2:34][CH3:35].[Cu:36][I:37]>>[c:2]1([C:27]#[C:26][CH2:25][CH2:24][C:23]([O:22][CH2:18][CH2:19][CH2:20][CH3:21])=[O:28])[cH:3][cH:4][cH:5][c:6]([NH:8][CH2:9][c:10]2[cH:11][cH:12][c:13]([O:16][CH3:17])[cH:14][cH:15]2)[n:7]1

Participants

5

Reactant 4

HCID 8471TriethylamineHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 23435506Pent-4-ynoic acid butyl esterHCID 234355096-Bromo-(4-methoxybenzylamino)pyridine

Product 1

HCID 696660335-[6-(4-Methoxy-benzylamino)-pyridin-2-yl]-pent-4-ynoic acid butyl ester

Sources & evidence

ORD record
ord-ec2c10a822934676874bd08a7efcb83d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

Loading…