Tetrahydrofuran → 6-(2-Hydroxy-benzyl)-5-{hydroxy-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methyl}-naphthalen-2-ol

HRID 662601Notes

Reaction equation

HRID 662601 reaction equation
[Al+3:2].[CH2:43]1[O:44][CH2:45][CH2:46][CH2:47]1.[H-:1].[H-:4].[H-:5].[H-:6].[Li+:3].[OH:7][c:8]1[cH:9][c:10]2[cH:11][cH:12][c:13]([CH2:35][c:36]3[c:37]([OH:42])[cH:38][cH:39][cH:40][cH:41]3)[c:14]([C:18](=[O:19])[c:20]3[cH:21][cH:22][c:23]([O:26][CH2:27][CH2:28][N:29]4[CH2:30][CH2:31][CH2:32][CH2:33][CH2:34]4)[cH:24][cH:25]3)[c:15]2[cH:16][cH:17]1>>[OH:7][c:8]1[cH:9][c:10]2[cH:11][cH:12][c:13]([CH2:35][c:36]3[c:37]([OH:42])[cH:38][cH:39][cH:40][cH:41]3)[c:14]([CH:18]([OH:19])[c:20]3[cH:21][cH:22][c:23]([O:26][CH2:27][CH2:28][N:29]4[CH2:30][CH2:31][CH2:32][CH2:33][CH2:34]4)[cH:24][cH:25]3)[c:15]2[cH:16][cH:17]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 104727Aluminum CationHCID 166653Hydride4×HCID 9982673[6-Hydroxy-2-(2-hydroxy-benzyl)-naphthalen-1-yl]-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone

Product 1

HCID 100509856-(2-Hydroxy-benzyl)-5-{hydroxy-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methyl}-naphthalen-2-ol

Sources & evidence

ORD record
ord-35cf0847175542dca071460a41ff1788
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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