Chloroform → tert-butyl 4-[2-[4-(acetyloxymethyl)phenyl]-2-(3,3-difluorocyclopentyl)-2-hydroxyacetyl]oxypiperidine-1-carboxylate

HRID 662607Notes

Reaction equation

HRID 662607 reaction equation
[CH3:34][N:35]([c:36]1[cH:37][cH:38][cH:39][cH:40][n:41]1)[CH3:42].[CH3:43][C:44](=[O:45])[O:46][C:47](=[O:48])[CH3:49].[CH3:54][CH2:55][N:56]([CH2:57][CH3:58])[CH2:59][CH3:60].[CH3:61][CH2:62][O:63][C:64](=[O:65])[CH3:66].[CH:50]([Cl:51])([Cl:52])[Cl:53].[F:1][C:2]1([F:33])[CH2:3][CH:4]([C:7]([C:8](=[O:9])[O:10][CH:11]2[CH2:12][CH2:13][N:14]([C:17](=[O:18])[O:19][C:20]([CH3:21])([CH3:22])[CH3:23])[CH2:15][CH2:16]2)([c:24]2[cH:25][cH:26][c:27]([CH2:30][OH:31])[cH:28][cH:29]2)[OH:32])[CH2:5][CH2:6]1>>[F:1][C:2]1([F:33])[CH2:3][CH:4]([C:7]([C:8](=[O:9])[O:10][CH:11]2[CH2:12][CH2:13][N:14]([C:17](=[O:18])[O:19][C:20]([CH3:21])([CH3:22])[CH3:23])[CH2:15][CH2:16]2)([c:24]2[cH:25][cH:26][c:27]([CH2:30][O:31][C:44]([CH3:43])=[O:45])[cH:28][cH:29]2)[OH:32])[CH2:5][CH2:6]1

Participants

7

Reactant 6

HCID 6212ChloroformHCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 218852-DimethylaminopyridineHCID 178452160HCID 178452160, compound

Product 1

HCID 178475846tert-butyl 4-[2-[4-(acetyloxymethyl)phenyl]-2-(3,3-difluorocyclopentyl)-2-hydroxyacetyl]oxypiperidine-1-carboxylate

Sources & evidence

ORD record
ord-4efa70fd7f404bddbcc2784be19a3fbc
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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