Hydrochloric Acid → HCID 20468376, compound

HRID 66282Notes

Reaction equation

HRID 66282 reaction equation
[F:1][C:2]1[CH:22]=[CH:21][CH:20]=[CH:19][C:3]=1[C:4]([N:6]1[CH2:11][CH:10]2[C:8]([C:12]3[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=3)([CH2:9]2)[CH2:7]1)=O.[H-].COCCO[Al+]OCCOC.[Na+].[H-].Cl>CCOCC>[ClH:18].[Cl:18][C:15]1[CH:16]=[CH:17][C:12]([C:8]23[CH2:9][CH:10]2[CH2:11][N:6]([CH2:4][C:3]2[CH:19]=[CH:20][CH:21]=[CH:22][C:2]=2[F:1])[CH2:7]3)=[CH:13][CH:14]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 204683333-(o-Fluorobenzoyl)-1-(p-chlorophenyl)-3-azabicyclo[3.1.0]hexaneHCID 21584525Sodium bis(2-methoxyethoxy)aluminiumhydride

Product 1

HCID 20468376HCID 20468376, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A 13.9 g portion of 3-(o-fluorobenzoyl)-1-(p-chlorophenyl)-3-azabicyclo[3.1.0]hexane is reacted as described in Example 19 with 50 ml of sodium bis(2-methoxyethoxy)aluminum hydride (70% benzene solution) yielding a light yellow oil. This base is treated with ethanolic hydrochloric acid and ether to give the hydrochloride as a white solid, mp 204°-206° C.

Workup

  1. customyielding a light yellow oil

Sources & evidence

ORD record
ord-e599dc8fb1914e0888bfb5af3bfef33f
Source dataset
uspto-grants-1978_12
Patent number
US04131611

Reaction notes

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