反应详情

To a stirred solution of 4-amino-1-(4-phenyl-4-oxobutyl)-piperidine dihydrochloride (1.752 g. 0.005 mole) and triethylamine (2 ml.) in CH2Cl2 (10 ml.) was added dropwise a solution of benzenesulphonyl chloride (0.883 g. 0.005 mole) in CH2Cl2 (5 ml.). The mixture was stirred for 24 hours and extracted with water (3 × 10 ml.). The organic phase was separated, dried (MgSO4) and evaporated to give a crystalline residue. Treatment of this with ethanolic HCl followed by diethyl ether afforded the title compound as the monohydrochloride, buff solid (1.961 g.), m.p. 195.2° C.

1. extractionextracted with water (3 × 10 ml.)
2. customThe organic phase was separated
3. dry with materialdried (MgSO4)
4. customevaporated
5. customto give a crystalline residue