反应详情

A mixture of 0.5 g of 2-(2-methoxyphenyl)oxirane (crude product) and 600 mg of 3,4-dimethoxyphenethylamine is heated at 130° to 140° C. for 2 hours. After cooling, chloroform is added to the reaction mixture, and said mixture is washed with water. The mixture is dried and evaporated to remove solvent. 2 ml of ethanol are added to the residue obtained. Then, hydrochloric acid-containing diethylether is added to the ethanol mixture, and crystalline precipitates are collected by filtration. 290 mg of α-(3,4-dimethoxyphenethylaminomethyl)-2-methoxybenzylalcohol hydrochloride are obtained as crystals. M.p. 142°-143° C.

1. temperatureis heated at 130° to 140° C. for 2 hours
2. temperatureAfter cooling
3. washis washed with water
4. customThe mixture is dried
5. customevaporated
6. customto remove solvent
7. addition2 ml of ethanol are added to the residue
8. customobtained
9. customcrystalline precipitates
10. filtrationare collected by filtration