反应详情

2 g of 2-ethoxyacetophenone are dissolved in 20 ml of dioxane, and a solution of 2 g of selenium dioxide in one ml of water is added thereto. The solution is refluxed for 10 hours. After the reaction, insoluble materials are removed by filtration, and the filtrate is concentrated. The residue thus obtained is dissolved in ethyl acetate. The ethyl acetate solution is washed with water and then with an aqueous sodium bicarbonate solution and water. Then, said solution is dried and evaporated to remove solvent. 2.1 g of 2-ethoxyphenylglyoxal are obtained as a crude oil.

1. temperatureThe solution is refluxed for 10 hours
2. customAfter the reaction, insoluble materials
3. customare removed by filtration
4. concentrationthe filtrate is concentrated
5. customThe residue thus obtained
6. washThe ethyl acetate solution is washed with water
7. customis dried
8. customevaporated
9. customto remove solvent