Dimethylformamide → (3,5-Difluoropyridin-2-yl)(3-fluoroazetidin-1-yl)methanone

HRID 664319Notes

Reaction equation

[CH3:17][CH2:18][N:19]([CH2:20][CH3:21])[CH2:22][CH3:23].[F:12][CH:13]1[CH2:14][NH:15][CH2:16]1.[F:1][c:2]1[c:3]([C:9](=[O:10])[OH:11])[n:4][cH:5][c:6]([F:8])[cH:7]1.[O:48]=[CH:49][N:50]([CH3:51])[CH3:52].[P-:24]([F:25])([F:26])([F:27])([F:28])([F:29])[F:30].[n:31]1([O:32][C:33]([N:34]([CH3:35])[CH3:36])=[N+:37]([CH3:38])[CH3:39])[c:40]2[n:41][cH:42][cH:43][cH:44][c:45]2[n:46][n:47]1>>[F:1][c:2]1[c:3]([C:9](=[O:11])[N:15]2[CH2:14][CH:13]([F:12])[CH2:16]2)[n:4][cH:5][c:6]([F:8])[cH:7]1

Participants

Reactant 6

HCID 6228Dimethylformamide

HCID 8471Triethylamine

HCID 9886Hexafluorophosphate

HCID 27832623,5-Difluoropyridine-2-carboxylic acid

HCID 36035423-Fluoroazetidine

HCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminium

Product 1

HCID 59559983(3,5-Difluoropyridin-2-yl)(3-fluoroazetidin-1-yl)methanone

Sources & evidence

ORD record: ord-b6892401acdb440baa5b9d791cf23ed4
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (3/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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