Ammonium → 3,4-Difluoro-4'-methoxy-1,1'-biphenyl

HRID 665167Notes

Reaction equation

HRID 665167 reaction equation
[Br-:1].[Br-:44].[CH2:2]([Mg+:3])[CH3:4].[CH2:56]1[O:57][CH2:58][CH2:59][CH2:60]1.[CH3:45][O:46][c:47]1[cH:48][cH:49][c:50]([Mg+:53])[cH:51][cH:52]1.[CH:6]([c:7]1[cH:8][cH:9][cH:10][c:11]([CH:12]([CH3:13])[CH3:14])[c:15]1[NH+:16]1[CH2:17][CH2:18][N:19]([c:20]2[c:21]([CH:22]([CH3:23])[CH3:24])[cH:25][cH:26][cH:27][c:28]2[CH:29]([CH3:30])[CH3:31])[CH2:32]1)([CH3:33])[CH3:34].[Cl-:54].[Cl-:5].[Cl:35][c:36]1[cH:37][c:38]([F:43])[c:39]([F:42])[cH:40][cH:41]1.[NH4+:55]>>[c:36]1(-[c:50]2[cH:49][cH:48][c:47]([O:46][CH3:45])[cH:52][cH:51]2)[cH:37][c:38]([F:43])[c:39]([F:42])[cH:40][cH:41]1

Participants

9

Reactant 8

HCID 223AmmoniumHCID 259Bromide ion2×HCID 312Chloride2×HCID 8028TetrahydrofuranHCID 1365194-Chloro-1,2-difluorobenzeneHCID 207322111,3-Bis(2,6-diisopropylphenyl)imidazoliniumHCID 178461628HCID 178461628, compoundHCID 178491919HCID 178491919, compound

Product 1

HCID 153121363,4-Difluoro-4'-methoxy-1,1'-biphenyl

Sources & evidence

ORD record
ord-9456d75fd5cf4d7ab31be70690e890fe
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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