1,2-Dichloroethane → N1-(3-Fluoro-4-(2-(1-methyl-1H-imidazol-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-N3-(2-methoxyphenyl)malonamide
Reaction equation
[CH2:50]([Cl:51])[CH2:52][Cl:53].[CH3:1][O:2][c:3]1[c:4]([NH:9][C:10]([CH2:11][C:12](=[O:13])[OH:14])=[O:15])[cH:5][cH:6][cH:7][cH:8]1.[F:26][c:27]1[cH:28][c:29]([NH2:49])[cH:30][cH:31][c:32]1[O:33][c:34]1[c:35]2[c:36]([n:37][cH:38][cH:39]1)[cH:40][c:41](-[c:43]1[n:44]([CH3:48])[cH:45][cH:46][n:47]1)[s:42]2.[Na+:58].[O-:54][C:55]([OH:56])=[O:57].[O:59]=[CH:60][N:61]([CH3:62])[CH3:63].[OH:16][n:17]1[c:18]2[c:19]([cH:20][cH:21][cH:22][cH:23]2)[n:24][n:25]1>>[CH3:1][O:2][c:3]1[c:4]([NH:9][C:10]([CH2:11][C:12](=[O:14])[NH:49][c:29]2[cH:28][c:27]([F:26])[c:32]([O:33][c:34]3[c:35]4[c:36]([n:37][cH:38][cH:39]3)[cH:40][c:41](-[c:43]3[n:44]([CH3:48])[cH:45][cH:46][n:47]3)[s:42]4)[cH:31][cH:30]2)=[O:15])[cH:5][cH:6][cH:7][cH:8]1Participants
8
Reactant 7
Product 1
Sources & evidence
- ORD record
- ord-aa647e2d881842d3bbbb5d5cdaee7bfa
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (3/10)
Reaction notes
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