Hydrochloric Acid → 2-ethoxymethyl-7-(pyridin-3-yl)-1-{[1-(tetrahydrofuran-2-ylcarbonyl)piperidin-4-yl]methyl}-1H-imidazo[4,5-c]quinolin-4-amine

HRID 665537Notes

Reaction equation

HRID 665537 reaction equation
[CH2:4]([CH3:5])[O:6][CH2:7][c:8]1[n:9]([CH2:28][CH:29]2[CH2:30][CH2:31][NH:32][CH2:33][CH2:34]2)[c:10]2[c:11]([c:12]([NH2:26])[n:13][c:14]3[cH:15][c:16](-[c:20]4[cH:21][n:22][cH:23][cH:24][cH:25]4)[cH:17][cH:18][c:19]23)[n:27]1.[CH3:35][CH2:36][N:37]([CH2:38][CH3:39])[CH2:40][CH3:41].[CH3:51][O:52][N:53]([O:54][CH3:55])[CH2:56][CH2:57][CH2:58][N:59]=[C:60]=[N:61][CH2:62][CH3:63].[CH:74]([Cl:75])([Cl:76])[Cl:77].[ClH:1].[ClH:2].[ClH:3].[ClH:50].[O:42]1[CH:43]([C:47](=[O:48])[OH:49])[CH2:44][CH2:45][CH2:46]1.[OH:64][n:65]1[c:66]2[cH:67][cH:68][cH:69][cH:70][c:71]2[n:72][n:73]1>>[CH2:4]([CH3:5])[O:6][CH2:7][c:8]1[n:9]([CH2:28][CH:29]2[CH2:30][CH2:31][N:32]([C:47]([CH:43]3[O:42][CH2:46][CH2:45][CH2:44]3)=[O:48])[CH2:33][CH2:34]2)[c:10]2[c:11]([c:12]([NH2:26])[n:13][c:14]3[cH:15][c:16](-[c:20]4[cH:21][n:22][cH:23][cH:24][cH:25]4)[cH:17][cH:18][c:19]23)[n:27]1

Participants

8

Reactant 7

HCID 313Hydrochloric Acid4×HCID 6212ChloroformHCID 8471TriethylamineHCID 757711-HydroxybenzotriazoleHCID 86079(+-)-Tetrahydro-2-furoic acidHCID 21984280HCID 21984280, compoundHCID 21984460HCID 21984460, compound

Product 1

HCID 219841412-ethoxymethyl-7-(pyridin-3-yl)-1-{[1-(tetrahydrofuran-2-ylcarbonyl)piperidin-4-yl]methyl}-1H-imidazo[4,5-c]quinolin-4-amine

Sources & evidence

ORD record
ord-b11c2f1a62c5481ca595894460988cde
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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