Chloride → [2-chloro-4-(4-chloro-2-fluoro-benzyloxy)-5-methoxy-phenyl]-(1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-methanol

HRID 665620Notes

Reaction equation

HRID 665620 reaction equation
[CH:22]([Mg+:23])([CH3:24])[CH3:25].[Cl-:21].[Cl:26][c:27]1[c:28]([CH:29]=[O:30])[cH:31][c:32]([O:45][CH3:46])[c:33]([O:35][CH2:36][c:37]2[c:38]([F:44])[cH:39][c:40]([Cl:43])[cH:41][cH:42]2)[cH:34]1.[I:1][c:2]1[cH:3][n:4]([Si:11]([CH:12]([CH3:13])[CH3:14])([CH:15]([CH3:16])[CH3:17])[CH:18]([CH3:19])[CH3:20])[c:5]2[n:6][cH:7][cH:8][cH:9][c:10]12.[O:47]1[CH2:48][CH2:49][CH2:50][CH2:51]1>>[c:2]1([CH:29]([c:28]2[c:27]([Cl:26])[cH:34][c:33]([O:35][CH2:36][c:37]3[c:38]([F:44])[cH:39][c:40]([Cl:43])[cH:41][cH:42]3)[c:32]([O:45][CH3:46])[cH:31]2)[OH:30])[cH:3][n:4]([Si:11]([CH:12]([CH3:13])[CH3:14])([CH:15]([CH3:16])[CH3:17])[CH:18]([CH3:19])[CH3:20])[c:5]2[n:6][cH:7][cH:8][cH:9][c:10]12

Participants

6

Reactant 5

HCID 312ChlorideHCID 8028TetrahydrofuranHCID 242292273-Iodo-1-[tris(1-methylethyl)silyl]-1H-pyrrolo[2,3-b]pyridineHCID 598038352-Chloro-4-(4-chloro-2-fluoro-benzyloxy)-5-methoxy-benzaldehydeHCID 178461726HCID 178461726, compound

Product 1

HCID 59803877[2-chloro-4-(4-chloro-2-fluoro-benzyloxy)-5-methoxy-phenyl]-(1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-methanol

Sources & evidence

ORD record
ord-4cb5dc6fab5c40b6b02d92c6845e0800
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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