Tetrahydrofuran → Tert-butyl-2-(1-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)benzoyl)-3-hydroxyazetidin-3-yl)cyclohexylcarbamate
Reaction equation
[CH:40]([N:41]([CH2:42][CH3:43])[CH:44]([CH3:45])[CH3:46])([CH3:47])[CH3:48].[F:20][c:21]1[c:22]([NH:31][c:32]2[c:33]([F:39])[cH:34][c:35]([I:38])[cH:36][cH:37]2)[c:23]([C:24](=[O:25])[F:26])[cH:27][cH:28][c:29]1[F:30].[O:49]1[CH2:50][CH2:51][CH2:52][CH2:53]1.[OH:1][C:2]1([CH:6]2[CH:7]([NH:12][C:13]([O:14][C:15]([CH3:16])([CH3:17])[CH3:18])=[O:19])[CH2:8][CH2:9][CH2:10][CH2:11]2)[CH2:3][NH:4][CH2:5]1>>[OH:1][C:2]1([CH:6]2[CH:7]([NH:12][C:13]([O:14][C:15]([CH3:16])([CH3:17])[CH3:18])=[O:19])[CH2:8][CH2:9][CH2:10][CH2:11]2)[CH2:3][N:4]([C:24]([c:23]2[c:22]([NH:31][c:32]3[c:33]([F:39])[cH:34][c:35]([I:38])[cH:36][cH:37]3)[c:21]([F:20])[c:29]([F:30])[cH:28][cH:27]2)=[O:25])[CH2:5]1Participants
5
Reactant 4
Product 1
Sources & evidence
- ORD record
- ord-63d36c2c290741379ce7d3421f508ef1
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (3/10)
Reaction notes
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