Dimethylformamide → 6-Chloro-2,4-difluoro-3-trimethylsilylbenzaldehyde

HRID 666667Notes

Reaction equation

HRID 666667 reaction equation
[CH2:30]1[O:31][CH2:32][CH2:33][CH2:34]1.[CH3:14][CH:15]1[CH2:16][CH2:17][CH2:18][N:19]([CH3:20])[C:21]1([CH3:22])[CH3:23].[Cl:1][c:2]1[cH:3][c:4]([F:13])[c:5]([Si:9]([CH3:10])([CH3:11])[CH3:12])[c:6]([F:8])[cH:7]1.[Li:24].[O:25]=[CH:26][N:27]([CH3:28])[CH3:29]>>[Cl:1][c:2]1[c:3]([CH:26]=[O:25])[c:4]([F:13])[c:5]([Si:9]([CH3:10])([CH3:11])[CH3:12])[c:6]([F:8])[cH:7]1

Participants

6

Reactant 5

HCID 6228DimethylformamideHCID 8028TetrahydrofuranHCID 3028194LithiumHCID 187617721,2,2,3-TetramethylpiperidineHCID 18935733(4-Chloro-2,6-difluorophenyl)trimethylsilane

Product 1

HCID 866138416-Chloro-2,4-difluoro-3-trimethylsilylbenzaldehyde

Sources & evidence

ORD record
ord-543f8ab4882e4bbd8beecd592c8d1d75
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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