反应详情

A mixture of 5.7 g (0.025 mole) 4-hydroxy-6-methyl-2-trichloromethylpyrimidine, 5.1 g (0.05 mole) triethylamine, and 100 ml acetonitrile was stirred and 5.4 g (0.05 mole) dimethylcarbamoyl chloride was added to the mixture. The reaction mixture was stirred 2 hours under reflux, and allowed to cool. A solid was filtered out after cooling and washed with water to give 3.6 g (48% yield; mp 83.5°-84.5° C.). The structure was confirmed via infrared and elemental analysis.

1. stirringThe reaction mixture was stirred 2 hours
2. temperatureunder reflux
3. temperatureto cool
4. filtrationA solid was filtered out
5. temperatureafter cooling
6. washwashed with water
7. customto give 3.6 g (48% yield; mp 83.5°-84.5° C.)