反应详情

A mixture of 3.9 g (0.015 mole) 5-chloro-4-hydroxy-6-methyl-2-trichloromethylpyrimidine, 1.6 g (0.015 mole) triethylamine, 1.7 g (0.015 mole) dimethylcarbamoyl chloride, and 80 ml acetonitrile was refluxed 3 days. Rotary evaporation to concentrate the solution yielded a precipitate that was removed by filtration. Rotary evaportation of the filtrate gave a residue which was triturated with petroleum ether to give 1.0 g (20% yield; mp 87°-88° C.) of product. The structure was confirmed via infrared and elemental analysis.

1. temperaturewas refluxed 3 days
2. customRotary evaporation
3. concentrationto concentrate the solution
4. customyielded a precipitate that
5. customwas removed by filtration
6. customRotary evaportation of the filtrate gave a residue which
7. customwas triturated with petroleum ether
8. customto give 1.0 g (20% yield; mp 87°-88° C.) of product