Phosphorus oxychloride → HCID 20528962, compound

HRID 66745Notes

Reaction equation

HRID 66745 reaction equation
N[C:2]1[C:7]([N:8]2[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)=[N:6][CH:5]=[C:4]([O:14][CH3:15])[N:3]=1.N([O-])=O.[Na+].P(Cl)(Cl)([Cl:22])=O>>[Cl:22][C:2]1[C:7]([N:8]2[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)=[N:6][CH:5]=[C:4]([O:14][CH3:15])[N:3]=1

Participants

4

Reactant 3

HCID 24813Phosphorus oxychlorideHCID 20528919HCID 20528919, compoundHCID 23668193Sodium Nitrite

Product 1

HCID 20528962HCID 20528962, compound

Procedure

The 2-amino substituent of Step A product when treated with sodium nitrite as described in Step E of Preparation 81 is converted to the 2-hydroxy group. Treatment of the 2-hydroxy-3-morpholino-6-methopxypyrazine with phosphorus oxychloride by Preparation 13, Step B method, gives 2-chloro-3-morpholino-6-methoxypyrazine.

Workup

  1. customas described in Step E of Preparation 81

Sources & evidence

ORD record
ord-246a6856eb474f1f861fd9865d10550f
Source dataset
uspto-grants-1982_08
Patent number
US04343802

Reaction notes

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