Phosphorus oxychloride → 2-Chloro-3,5-dimorpholinopyrazine

HRID 66754Notes

Reaction equation

N[C:2]1[C:7]([N:8]2[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)=[N:6][C:5]([N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)=[CH:4][N:3]=1.N([O-])=O.[Na+].P(Cl)(Cl)([Cl:26])=O>>[Cl:26][C:2]1[C:7]([N:8]2[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)=[N:6][C:5]([N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)=[CH:4][N:3]=1

Participants

Reactant 3

HCID 24813Phosphorus oxychloride

HCID 205289312-Amino-3,5-dimorpholinopyrazine

HCID 23668193Sodium Nitrite

Product 1

HCID 205289902-Chloro-3,5-dimorpholinopyrazine

Procedure

This product is obtained by treating the 2-amino-3,5-dimorpholinopyrazine with sodium nitrite by the method described in the preceding procedure, Step C, and then with phosphorus oxychloride by the method described in Preparation 13, Step B.

Workup

customThis product is obtained

Sources & evidence

ORD record: ord-33d1fe42ea6b4301866234e57d234b2a
Source dataset: uspto-grants-1982_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04343802

Reaction notes

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