Hydrochloric Acid → N-(1-(2-Chloropyridin-4-yl)piperidin-4-yl)-8-(3,4-difluorophenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine

HRID 667865Notes

Reaction equation

HRID 667865 reaction equation
[Br:17][c:18]1[n:19][n:20]2[c:21]([c:22](-[c:26]3[cH:27][c:28]([F:33])[c:29]([F:32])[cH:30][cH:31]3)[cH:23][cH:24][cH:25]2)[n:34]1.[CH:144]([Cl:145])([Cl:146])[Cl:147].[Cl:3][c:4]1[n:5][cH:6][cH:7][c:8]([N:10]2[CH2:11][CH2:12][CH:13]([NH2:16])[CH2:14][CH2:15]2)[cH:9]1.[Cl:85][CH2:86][Cl:87].[ClH:1].[ClH:2].[Na+:84].[O-:77][c:78]1[cH:79][cH:80][cH:81][cH:82][cH:83]1.[O:108]=[C:109]([CH:110]=[CH:111][c:112]1[cH:113][cH:114][cH:115][cH:116][cH:117]1)[CH:118]=[CH:119][c:120]1[cH:121][cH:122][cH:123][cH:124][cH:125]1.[O:126]=[C:127]([CH:128]=[CH:129][c:130]1[cH:131][cH:132][cH:133][cH:134][cH:135]1)[CH:136]=[CH:137][c:138]1[cH:139][cH:140][cH:141][cH:142][cH:143]1.[O:90]=[C:91]([CH:92]=[CH:93][c:94]1[cH:95][cH:96][cH:97][cH:98][cH:99]1)[CH:100]=[CH:101][c:102]1[cH:103][cH:104][cH:105][cH:106][cH:107]1.[Pd:88].[Pd:89].[c:35]1([P:36]([c:37]2[cH:38][cH:39][cH:40][cH:41][cH:42]2)[c:43]2[c:44]3[c:68]([cH:69][cH:70][cH:71]2)[C:65]([CH3:66])([CH3:67])[c:47]2[c:46]([c:51]([P:52]([c:53]4[cH:54][cH:55][cH:56][cH:57][cH:58]4)[c:59]4[cH:60][cH:61][cH:62][cH:63][cH:64]4)[cH:50][cH:49][cH:48]2)[O:45]3)[cH:72][cH:73][cH:74][cH:75][cH:76]1>>[Cl:3][c:4]1[n:5][cH:6][cH:7][c:8]([N:10]2[CH2:11][CH2:12][CH:13]([NH:16][c:18]3[n:19][n:20]4[c:21]([c:22](-[c:26]5[cH:27][c:28]([F:33])[c:29]([F:32])[cH:30][cH:31]5)[cH:23][cH:24][cH:25]4)[n:34]3)[CH2:14][CH2:15]2)[cH:9]1

Participants

11

Reactant 10

HCID 313Hydrochloric Acid2×HCID 923Sodium ionHCID 6212ChloroformHCID 6344DichloromethaneHCID 23938Palladium2×HCID 95417Dibenzylidene acetone3×HCID 119047PhenolateHCID 6360441,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine)HCID 673424362-Bromo-8-(3,4-difluorophenyl)-[1,2,4]triazolo[1,5-a]pyridineHCID 866567101-(2-Chloro-4-pyridinyl)piperidin-4-amine

Product 1

HCID 58398048N-(1-(2-Chloropyridin-4-yl)piperidin-4-yl)-8-(3,4-difluorophenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine

Sources & evidence

ORD record
ord-59804dc6c4044a15a1dc53e7cbe7ff3e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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