反应详情

An amount of 3.21 g (9.25 m mole) of 5-benzyloxy-3-(3-chloro-phenyl)-2-methyl-1H-indole was dissolved in 50 ml of absolute dimethylformamide, and the solution was mixed with 406 mg (9.3 m mole) of 55% sodium hydride in paraffin oil. After one hour 1.45 g (10.2 m mole) of methyliodide were added, and the mixture was stirred overnight. After evaporation, the reaction mixture was mixed with water and extracted with chloroform. The extracts, which were dried over sodium sulfate, were evaporated, and the residue obtained was purified by chromatography on silicagel by using toluene as solvent.

1. customAfter evaporation
2. additionthe reaction mixture was mixed with water
3. extractionextracted with chloroform
4. dry with materialThe extracts, which were dried over sodium sulfate
5. customwere evaporated
6. customthe residue obtained
7. customwas purified by chromatography on silicagel