反应详情

An amount of 3.6 g (0.015 mole) of 2-bromo-propiophenone and 6 g (0.03 mole) of 4-benzyloxy-aniline were refluxed for two hours in 15 ml of triethylamine. The mixture was evaporated to dryness, and the residue was heated for two hours to 180° C. After cooling, the residue was mixed with 10% hydrochloric acid and extracted with chloroform. The extracts were dried over sodium sulfate, filtered, and evaporated. The residue obtained was purified by column chromatography on silicagel with toluene as solvent.

1. customThe mixture was evaporated to dryness
2. temperaturethe residue was heated for two hours to 180° C
3. temperatureAfter cooling
4. additionthe residue was mixed with 10% hydrochloric acid
5. extractionextracted with chloroform
6. dry with materialThe extracts were dried over sodium sulfate
7. filtrationfiltered
8. customevaporated
9. customThe residue obtained
10. customwas purified by column chromatography on silicagel with toluene as solvent