Hydrochloric Acid → 2-[7,8-Dihydro-9-(4-pyridyl)-6H-pyrrolo[1,2-a]indole-2-yloxy]-2-methyl-propanoic acid hydrochloride

HRID 66887Notes

Reaction equation

HRID 66887 reaction equation
C([O:3][C:4](=[O:27])[C:5]([O:8][C:9]1[CH:10]=[C:11]2[C:19]([C:20]3[CH:25]=[CH:24][N:23]=[CH:22][CH:21]=3)=[C:18]3[C:13](=[CH:14][CH2:15][CH2:16][CH2:17]3)[N:12]2[CH:26]=1)([CH3:7])[CH3:6])C.[ClH:28]>>[ClH:28].[N:23]1[CH:24]=[CH:25][C:20]([C:19]2[C:11]3[N:12]([CH:26]=[C:9]([O:8][C:5]([CH3:7])([CH3:6])[C:4]([OH:27])=[O:3])[CH:10]=3)[C:13]3[C:18]=2[CH2:17][CH2:16][CH2:15][CH:14]=3)=[CH:21][CH:22]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 54141958HCID 54141958, compound

Product 1

HCID 705485892-[7,8-Dihydro-9-(4-pyridyl)-6H-pyrrolo[1,2-a]indole-2-yloxy]-2-methyl-propanoic acid hydrochloride

Procedure

The above compound was prepared from 2-[7,8dihydro9-(4-pyridyl)-6H-pyrrolo[1,2-a]indole-2-yloxy]-2-methyl-propanoic acid ethylester by alkaline hydrolysis using a procedure analogous to that of Example 66. When the aqueous alkaline solution was acidified with 2N hydrochloric acid, the hydrochloride precipitated, which was then recrystillzed from ethanol.

Workup

  1. customthe hydrochloride precipitated

Sources & evidence

ORD record
ord-c7d2e9142e68488599590cfbc6910a17
Source dataset
uspto-grants-1982_08
Patent number
US04343811

Reaction notes

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