反应详情

An amount of 0.5 g (1.4 m mole) of 2-[3-(4-chlorophenyl)-1,2-dimethyl-1H-indole-5yloxy]-2-methyl-propanoic acid was dissolved in 25 ml of tetrahydrofurane and heated for four hours with 0.24 g (1.4 m mole) of N,N'-carbonyldiimidazole on a steam bath. Subsequently, 0.24 g (2.8 m mole) of piperidine were added, and the mixture was refluxed for 12 hours. After evaporation the residue was mixed with dilute hydrochloric acid and extracted with ether. The evaporated ether residue was purified by column chromatography with toluene/ethyl acetate (8:2) on silicagel.

1. temperaturethe mixture was refluxed for 12 hours
2. customAfter evaporation the residue
3. additionwas mixed with dilute hydrochloric acid
4. extractionextracted with ether
5. customThe evaporated ether residue was purified by column chromatography with toluene/ethyl acetate (8:2) on silicagel