反应详情

A solution of 4,4'-bis(N,N-dimethylamino)benzhydrol, methyl ether (11.0 g, 0.039 mole), benzyl glycolate (6.6 g, 0.039 mole), 90 ml of tetrahydrofuran, 200 ml of hexane, and 10 drops of methanesulfonic acid was refluxed for 6 hours, replacing solvent as distillate was removed; then, 10 drops of tetramethylguanidine was added to discharge the color and the reaction mixture was filtered hot and cooled. A white solid formed which was filtered, washed with petroleum ether and then recrystallized from 4/1 hexane/acetone. The resulting white crystalline product had a mp 101.8°-103° C.

1. customwas removed
2. additionthen, 10 drops of tetramethylguanidine was added
3. filtrationthe reaction mixture was filtered hot
4. temperaturecooled
5. customA white solid formed which
6. filtrationwas filtered
7. washwashed with petroleum ether
8. customrecrystallized from 4/1 hexane/acetone