Oxalyl chloride → 3-Hydroxy-4-oxo-3-[(trimethylazaniumyl)methyl]pentanoate

HRID 66947Notes

Reaction equation

HRID 66947 reaction equation
Cl.[C:2]([C:5]([CH2:12][C:13](=[O:15])[O-:14])([CH2:7][N+:8]([CH3:11])([CH3:10])[CH3:9])[OH:6])(=[O:4])[CH3:3].C(Cl)(=O)C(Cl)=O>>[C:2]([C:5]([CH2:12][C:13](=[O:14])[O-:15])([CH2:7][N+:8]([CH3:9])([CH3:11])[CH3:10])[OH:6])(=[O:4])[CH3:3]

Participants

3

Reactant 2

HCID 65578Oxalyl chlorideHCID 129850230Acetyl carnitine hydrochloride

Product 1

HCID 1296278483-Hydroxy-4-oxo-3-[(trimethylazaniumyl)methyl]pentanoate

Procedure

To acetyl carnitine hydrochloride (1.2 g; 0.005 moles) oxalyl chloride (2.5 ml; 0.029 moles) was added and the resulting mixture was kept under stirring at room temperature for 2 hours. The mixture was then dried under vacuum, the residue was washed three times with anhydrous ethyl ether, thus obtaining the acid chloride of acetyl carnitine which was used as such in the next step.

Workup

  1. customThe mixture was then dried under vacuum
  2. washthe residue was washed three times with anhydrous ethyl ether

Sources & evidence

ORD record
ord-1cc4b4e3d2c44144bbcf3082faeec084
Source dataset
uspto-grants-1982_08
Patent number
US04343947

Reaction notes

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