Dimethylformamide → Tert-butyl 2-(4-amino-3-bromophenyl)morpholine-4-carboxylate

HRID 670012Notes

Reaction equation

HRID 670012 reaction equation
[CH3:29][CH2:30][O:31][C:32]([CH3:33])=[O:34].[NH2:1][c:2]1[cH:3][cH:4][c:5]([CH:8]2[O:9][CH2:10][CH2:11][N:12]([C:14](=[O:15])[O:16][C:17]([CH3:18])([CH3:19])[CH3:20])[CH2:13]2)[cH:6][cH:7]1.[O:21]=[C:22]1[N:23]([Br:28])[C:24](=[O:25])[CH2:26][CH2:27]1.[O:35]=[CH:36][N:37]([CH3:38])[CH3:39]>>[NH2:1][c:2]1[c:3]([Br:28])[cH:4][c:5]([CH:8]2[O:9][CH2:10][CH2:11][N:12]([C:14](=[O:15])[O:16][C:17]([CH3:18])([CH3:19])[CH3:20])[CH2:13]2)[cH:6][cH:7]1

Participants

5

Reactant 4

HCID 6228DimethylformamideHCID 8857Ethyl AcetateHCID 67184N-bromobutanimideHCID 58315596tert-Butyl 2-(4-aminophenyl)morpholine-4-carboxylate

Product 1

HCID 71743185Tert-butyl 2-(4-amino-3-bromophenyl)morpholine-4-carboxylate

Sources & evidence

ORD record
ord-387f62e61581455390a227d4791afcc4
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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