Hydrochloric Acid → N-{3-chloro-4-[(6-methylpyridin-2-yl)methoxy]phenyl}-5,8-dihydro-6H-spiro[1-benzothieno[2,3-d]pyrimidine-7,2'-[1,3]dioxolan]-4-amine

HRID 670690Notes

Reaction equation

HRID 670690 reaction equation
[CH:1]([OH:2])([CH3:3])[CH3:4].[Cl:23][c:24]1[cH:25][c:26]([NH2:27])[cH:28][cH:29][c:30]1[O:31][CH2:32][c:33]1[n:34][c:35]([CH3:39])[cH:36][cH:37][cH:38]1.[Cl:5][c:6]1[c:7]2[c:8]([n:9][cH:10][n:11]1)[s:12][c:13]1[c:14]2[CH2:15][CH2:16][C:17]2([CH2:18]1)[O:19][CH2:20][CH2:21][O:22]2.[ClH:40].[O:41]1[CH2:42][CH2:43][O:44][CH2:45][CH2:46]1>>[c:6]1([NH:27][c:26]2[cH:25][c:24]([Cl:23])[c:30]([O:31][CH2:32][c:33]3[n:34][c:35]([CH3:39])[cH:36][cH:37][cH:38]3)[cH:29][cH:28]2)[c:7]2[c:8]([n:9][cH:10][n:11]1)[s:12][c:13]1[c:14]2[CH2:15][CH2:16][C:17]2([CH2:18]1)[O:19][CH2:20][CH2:21][O:22]2

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 3776IsopropanolHCID 312751,4-DioxaneHCID 179901054-chloro-5,8-dihydro-6H-spiro[1-benzothieno[2,3-d]pyrimidine-7,2'-[1,3]dioxolane]HCID 220552383-Chloro-4-[(6-methylpyridin-2-yl)methoxy]aniline

Product 1

HCID 58346456N-{3-chloro-4-[(6-methylpyridin-2-yl)methoxy]phenyl}-5,8-dihydro-6H-spiro[1-benzothieno[2,3-d]pyrimidine-7,2'-[1,3]dioxolan]-4-amine

Sources & evidence

ORD record
ord-af29441860fb43739240364349fb556a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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