Hydrochloric Acid → Ethyl 3-amino-4-(2-methoxyphenyl)-2-methylbutanoate

HRID 670717Notes

Reaction equation

HRID 670717 reaction equation
[BH4-:25].[Br:17][CH:18]([C:19](=[O:20])[O:21][CH2:22][CH3:23])[CH3:24].[CH2:31]1[O:32][CH2:33][CH2:34][CH2:35]1.[CH3:1][Si:2]([CH3:3])([CH3:4])[Cl:5].[CH3:37][CH2:38][OH:39].[CH3:6][O:7][c:8]1[c:9]([CH2:10][C:11]#[N:12])[cH:13][cH:14][cH:15][cH:16]1.[Cl:28][CH2:29][Cl:30].[ClH:27].[Na+:26].[Zn:36]>>[CH3:6][O:7][c:8]1[c:9]([CH2:10][CH:11]([NH2:12])[CH:18]([C:19](=[O:20])[O:21][CH2:22][CH3:23])[CH3:24])[cH:13][cH:14][cH:15][cH:16]1

Participants

11

Reactant 10

HCID 313Hydrochloric AcidHCID 702EthanolHCID 923Sodium ionHCID 6344DichloromethaneHCID 6397ChlorotrimethylsilaneHCID 8028TetrahydrofuranHCID 23994ZincHCID 28123BorohydrideHCID 79040Ethyl 2-bromopropionateHCID 81496(2-Methoxyphenyl)acetonitrile

Product 1

HCID 10988741Ethyl 3-amino-4-(2-methoxyphenyl)-2-methylbutanoate

Sources & evidence

ORD record
ord-2dc836dfc68246b582d110847f3f4bf9
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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