反应详情

In this reference example, 4.04 g of 1-benzyl-4-[N-(o-aminobenzyl)-amino]-piperidine trihydrochloride, 3.04 g of triethylamine, 2.03 g of 1,1'-carbonyldiimidazole and 50 ml of acetonitrile are mixed and stirred at room temperature for 4 hours. Then, 0.8 g of 1,1'-carbonyldiimidazole is further added to the mixture and the resultant mixture is refluxed with heating for 20 minutes. The solution is cooled to room temperature. The crystals deposited are separated by filtration, washed with water and dried to obtain 2.50 g of a crude product. The crude product is recrystallized from hot ethanol to obtain 1.75 g of the desired product.

1. temperaturewith heating for 20 minutes
2. temperatureThe solution is cooled to room temperature
3. customThe crystals deposited are separated by filtration
4. washwashed with water
5. customdried
6. customto obtain 2.50 g of a crude product
7. customThe crude product is recrystallized from hot ethanol