Formamide → 4-Chloroquinazoline

HRID 670950Notes

Reaction equation

HRID 670950 reaction equation
[CH:11]([NH2:12])=[O:13].[Cl:25][P:26]([Cl:27])([Cl:28])([Cl:29])[Cl:30].[O:31]1[CH2:32][CH2:33][O:34][CH2:35][CH2:36]1.[OH:14][c:15]1[c:16]2[c:17]([cH:18][cH:19][cH:20][cH:21]2)[n:22][cH:23][n:24]1.[P:37]([Cl:38])([Cl:39])([Cl:40])=[O:41].[cH:1]1[cH:2][cH:3][c:4]2[n:5][cH:6][n:7][cH:8][c:9]2[cH:10]1>>[cH:1]1[cH:2][cH:3][c:4]2[n:5][cH:6][n:7][c:8]([Cl:25])[c:9]2[cH:10]1

Participants

7

Reactant 6

HCID 713FormamideHCID 9210QuinazolineHCID 24813Phosphorus oxychlorideHCID 24819Phosphorus pentachlorideHCID 312751,4-DioxaneHCID 178517962HCID 178517962, compound

Product 1

HCID 788644-Chloroquinazoline

Sources & evidence

ORD record
ord-308eba670dac440aa5adc21dc9d620e2
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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