Dimethylformamide → tert-butyl 4-(1-(4-chlorophenyl)-2-(1-trityl-1H-imidazol-2-yl)ethylcarbamoyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-ylcarbamate

HRID 671122Notes

Reaction equation

HRID 671122 reaction equation
[C:25]([CH3:26])([CH3:27])([CH3:28])[O:29][C:30](=[O:31])[NH:32][C:33]1([C:48](=[O:49])[OH:50])[CH2:34][CH2:35][N:36]([c:39]2[c:40]3[c:41]([n:42][cH:43][n:44]2)[nH:45][cH:46][cH:47]3)[CH2:37][CH2:38]1.[CH2:85]([N:86]([CH:87]([CH3:88])[CH3:89])[CH:90]([CH3:91])[CH3:92])[CH3:93].[Cl:51][c:52]1[cH:53][cH:54][c:55]([CH:58]([CH2:59][c:60]2[n:61]([C:65]([c:66]3[cH:67][cH:68][cH:69][cH:70][cH:71]3)([c:72]3[cH:73][cH:74][cH:75][cH:76][cH:77]3)[c:78]3[cH:79][cH:80][cH:81][cH:82][cH:83]3)[cH:62][cH:63][n:64]2)[NH2:84])[cH:56][cH:57]1.[O:94]=[CH:95][N:96]([CH3:97])[CH3:98].[P-:1]([F:2])([F:3])([F:4])([F:5])([F:6])[F:7].[n:8]1([O:9][C:10]([N:11]([CH3:12])[CH3:13])=[N+:14]([CH3:15])[CH3:16])[c:17]2[n:18][cH:19][cH:20][cH:21][c:22]2[n:23][n:24]1>>[C:25]([CH3:26])([CH3:27])([CH3:28])[O:29][C:30](=[O:31])[NH:32][C:33]1([C:48](=[O:50])[NH:84][CH:58]([c:55]2[cH:54][cH:53][c:52]([Cl:51])[cH:57][cH:56]2)[CH2:59][c:60]2[n:61]([C:65]([c:66]3[cH:67][cH:68][cH:69][cH:70][cH:71]3)([c:72]3[cH:73][cH:74][cH:75][cH:76][cH:77]3)[c:78]3[cH:79][cH:80][cH:81][cH:82][cH:83]3)[cH:62][cH:63][n:64]2)[CH2:34][CH2:35][N:36]([c:39]2[c:40]3[c:41]([n:42][cH:43][n:44]2)[nH:45][cH:46][cH:47]3)[CH2:37][CH2:38]1

Participants

7

Reactant 6

HCID 6228DimethylformamideHCID 9886HexafluorophosphateHCID 81531DiisopropylethylamineHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 577503944-((tert-Butoxycarbonyl)amino)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxylic acidHCID 577504101-(4-chlorophenyl)-2-(1-trityl-1H-imidazol-2-yl)ethanamine

Product 1

HCID 57750358tert-butyl 4-(1-(4-chlorophenyl)-2-(1-trityl-1H-imidazol-2-yl)ethylcarbamoyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-ylcarbamate

Sources & evidence

ORD record
ord-be4d91238804459bb64619831a04d167
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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