Hydrochloric Acid → (+/-)-1-(5-Chloro-2-ethoxycarbonylmethoxy-phenyl)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid 2-bromo-benzyl ester

HRID 671996Notes

Reaction equation

HRID 671996 reaction equation
[CH2:2]([CH3:3])[O:4][C:5]([CH2:6][O:7][c:8]1[c:9]([CH:15]2[NH:16][CH2:17][CH2:18][c:19]3[cH:20][cH:21][cH:22][cH:23][c:24]32)[cH:10][c:11]([Cl:14])[cH:12][cH:13]1)=[O:25].[CH:26]([N:27]([CH2:28][CH3:29])[CH:30]([CH3:31])[CH3:32])([CH3:33])[CH3:34].[Cl:54][CH2:55][Cl:56].[ClH:1].[O:35]=[C:36]1[CH2:37][CH2:38][C:39](=[O:40])[N:41]1[O:42][C:43]([O:44][CH2:45][c:46]1[c:47]([Br:52])[cH:48][cH:49][cH:50][cH:51]1)=[O:53]>>[CH2:2]([CH3:3])[O:4][C:5]([CH2:6][O:7][c:8]1[c:9]([CH:15]2[N:16]([C:43](=[O:42])[O:44][CH2:45][c:46]3[c:47]([Br:52])[cH:48][cH:49][cH:50][cH:51]3)[CH2:17][CH2:18][c:19]3[cH:20][cH:21][cH:22][cH:23][c:24]32)[cH:10][c:11]([Cl:14])[cH:12][cH:13]1)=[O:25]

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 6344DichloromethaneHCID 81531DiisopropylethylamineHCID 598169N-(2-Bromobenzyloxycarbonyloxy)succinimideHCID 66653751(+/-)-[4-Chloro-2-(1,2,3,4-tetrahydro-isoquinolin-1-yl)-phenoxy]-acetic acid ethyl ester

Product 1

HCID 86682585(+/-)-1-(5-Chloro-2-ethoxycarbonylmethoxy-phenyl)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid 2-bromo-benzyl ester

Sources & evidence

ORD record
ord-5132f2b34a214a0a82761a2e4d122cf1
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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