Dimethylformamide → 4-Fluoro-2-(4-fluorophenyl)-N-methyl-5-(2-methyl-5-(1-(4-methylpyrimidin-2-yl)cyclopropylcarbamoyl)phenyl)benzofuran-3-carboxamide

HRID 672382Notes

Reaction equation

HRID 672382 reaction equation
[CH3:32][c:33]1[n:34][c:35]([C:39]2([NH2:42])[CH2:40][CH2:41]2)[n:36][cH:37][cH:38]1.[CH3:43][CH2:44][N:45]([CH2:46][CH3:47])[CH2:48][CH3:49].[F:1][c:2]1[c:3](-[c:22]2[cH:23][c:24]([C:25](=[O:26])[OH:27])[cH:28][cH:29][c:30]2[CH3:31])[cH:4][cH:5][c:6]2[c:7]1[c:8]([C:18]([NH:19][CH3:20])=[O:21])[c:9](-[c:11]1[cH:12][cH:13][c:14]([F:17])[cH:15][cH:16]1)[o:10]2.[O:50]=[CH:51][N:52]([CH3:53])[CH3:54]>>[F:1][c:2]1[c:3](-[c:22]2[cH:23][c:24]([C:25](=[O:26])[NH:42][C:39]3([c:35]4[n:34][c:33]([CH3:32])[cH:38][cH:37][n:36]4)[CH2:40][CH2:41]3)[cH:28][cH:29][c:30]2[CH3:31])[cH:4][cH:5][c:6]2[c:7]1[c:8]([C:18]([NH:19][CH3:20])=[O:21])[c:9](-[c:11]1[cH:12][cH:13][c:14]([F:17])[cH:15][cH:16]1)[o:10]2

Participants

5

Reactant 4

HCID 6228DimethylformamideHCID 8471TriethylamineHCID 592756803-(4-Fluoro-2-(4-fluorophenyl)-3-(methylcarbamoyl)benzofuran-5-yl)-4-methylbenzoic acidHCID 67292323HCID 67292323, compound

Product 1

HCID 595051464-Fluoro-2-(4-fluorophenyl)-N-methyl-5-(2-methyl-5-(1-(4-methylpyrimidin-2-yl)cyclopropylcarbamoyl)phenyl)benzofuran-3-carboxamide

Sources & evidence

ORD record
ord-404a9658a9d24394966791aabd026b77
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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