Dichloromethane → 8-carbamoyl-7-chloro-6-phenyl-3,4-dihydro-1H-pyrrolo[1,2-a]pyrazine-2-carboxylic acid phenyl ester

HRID 673360Notes

Reaction equation

HRID 673360 reaction equation
[CH3:27][CH2:28][N:29]([CH2:30][CH3:31])[CH2:32][CH3:33].[Cl:34][C:35](=[O:36])[O:37][c:38]1[cH:39][cH:40][cH:41][cH:42][cH:43]1.[Cl:44][CH2:45][Cl:46].[Cl:8][c:9]1[c:10]([C:24](=[O:25])[NH2:26])[c:11]2[n:12]([c:17]1-[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1)[CH2:13][CH2:14][NH:15][CH2:16]2.[F:1][C:2]([F:3])([F:4])[C:5]([OH:6])=[O:7]>>[Cl:8][c:9]1[c:10]([C:24](=[O:25])[NH2:26])[c:11]2[n:12]([c:17]1-[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1)[CH2:13][CH2:14][N:15]([C:35](=[O:36])[O:37][c:38]1[cH:39][cH:40][cH:41][cH:42][cH:43]1)[CH2:16]2

Participants

6

Reactant 5

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 8471TriethylamineHCID 15891Phenyl chloroformateHCID 68886671HCID 68886671, compound

Product 1

HCID 587619138-carbamoyl-7-chloro-6-phenyl-3,4-dihydro-1H-pyrrolo[1,2-a]pyrazine-2-carboxylic acid phenyl ester

Sources & evidence

ORD record
ord-8d337f092a024556b827d5b5b22e4f98
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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