Tetrahydrofuran → N-(2-(1-hydroxy-3,3-dimethyl-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)propan-2-yl)-5-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)indolizine-8-carboxamide

HRID 673546Notes

Reaction equation

HRID 673546 reaction equation
[CH2:80]1[O:81][CH2:82][CH2:83][CH2:84]1.[CH:41]([N:42]([CH2:43][CH3:44])[CH:45]([CH3:46])[CH3:47])([CH3:48])[CH3:49].[Cl:50][c:51]1[cH:52][c:53]([C:59]2([C:76]([F:77])([F:78])[F:79])[CH2:60][C:61]([c:64]3[n:65]4[cH:66][cH:67][cH:68][c:69]4[c:70]([C:73](=[O:74])[OH:75])[cH:71][cH:72]3)=[N:62][O:63]2)[cH:54][c:55]([Cl:58])[c:56]1[Cl:57].[NH2:1][C:2]([CH3:3])([CH3:4])[c:5]1[cH:6][cH:7][c:8]2[c:9]([cH:16]1)[B:10]([OH:15])[O:11][C:12]2([CH3:13])[CH3:14].[P-:17]([F:18])([F:19])([F:20])([F:21])([F:22])[F:23].[n:24]1([O:25][C:26]([N:27]([CH3:28])[CH3:29])=[N+:30]([CH3:31])[CH3:32])[c:33]2[n:34][cH:35][cH:36][cH:37][c:38]2[n:39][n:40]1>>[NH:1]([C:2]([CH3:3])([CH3:4])[c:5]1[cH:6][cH:7][c:8]2[c:9]([cH:16]1)[B:10]([OH:15])[O:11][C:12]2([CH3:13])[CH3:14])[C:73]([c:70]1[c:69]2[n:65]([c:64]([C:61]3=[N:62][O:63][C:59]([c:53]4[cH:52][c:51]([Cl:50])[c:56]([Cl:57])[c:55]([Cl:58])[cH:54]4)([C:76]([F:77])([F:78])[F:79])[CH2:60]3)[cH:72][cH:71]1)[cH:66][cH:67][cH:68]2)=[O:74]

Participants

7

Reactant 6

HCID 8028TetrahydrofuranHCID 9886HexafluorophosphateHCID 81531DiisopropylethylamineHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 866854976-(2-aminopropan-2-yl)-3,3-dimethylbenzo[c][1,2]-oxaborol-1(3H)-olHCID 866855245-(5-(3,4,5-Trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)indolizine-8-carboxylic acid

Product 1

HCID 71575948N-(2-(1-hydroxy-3,3-dimethyl-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)propan-2-yl)-5-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)indolizine-8-carboxamide

Sources & evidence

ORD record
ord-ef96e2620ddb4f76958825a6da21c536
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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