Tetrahydrofuran → N-[6-chloro-4-(hydroxymethyl)pyridin-2-yl]-N-propylmethanesulfonamide

HRID 673646Notes

Reaction equation

[BH4-:20].[CH2:22]1[O:23][CH2:24][CH2:25][CH2:26]1.[Cl:1][c:2]1[cH:3][c:4]([C:5](=[O:6])[O:7][CH3:8])[cH:9][c:10]([N:12]([CH2:13][CH2:14][CH3:15])[S:16](=[O:17])(=[O:18])[CH3:19])[n:11]1.[Li+:21]>>[Cl:1][c:2]1[cH:3][c:4]([CH2:5][OH:6])[cH:9][c:10]([N:12]([CH2:13][CH2:14][CH3:15])[S:16](=[O:17])(=[O:18])[CH3:19])[n:11]1

Participants

Reactant 4

HCID 8028Tetrahydrofuran

HCID 28123Borohydride

HCID 28486Lithium ion

HCID 57434730Methyl 2-chloro-6-[(methylsulfonyl)(propyl)amino]isonicotinate

Product 1

HCID 57775667N-[6-chloro-4-(hydroxymethyl)pyridin-2-yl]-N-propylmethanesulfonamide

Sources & evidence

ORD record: ord-5194f7aa2fe44b52843bf521abc2f660
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (3/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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