Tetrahydrofuran → (1-Cyanocyclopropyl)-2-bromomethylcyclohexanecarboxamide

HRID 673891Notes

Reaction equation

[Br:36][N:37]1[C:38](=[O:39])[CH2:40][CH2:41][C:42]1=[O:43].[C:1](#[N:2])[C:3]1([C:6]2([C:14](=[O:15])[NH2:16])[CH:7]([CH2:12][OH:13])[CH2:8][CH2:9][CH2:10][CH2:11]2)[CH2:4][CH2:5]1.[O:44]1[CH2:45][CH2:46][CH2:47][CH2:48]1.[c:17]1([P:18]([c:19]2[cH:20][cH:21][cH:22][cH:23][cH:24]2)[c:25]2[cH:26][cH:27][cH:28][cH:29][cH:30]2)[cH:31][cH:32][cH:33][cH:34][cH:35]1>>[C:1](#[N:2])[C:3]1([C:6]2([C:14](=[O:15])[NH2:16])[CH:7]([CH2:12][Br:36])[CH2:8][CH2:9][CH2:10][CH2:11]2)[CH2:4][CH2:5]1

Participants

Reactant 4

HCID 8028Tetrahydrofuran

HCID 11776Triphenylphosphine

HCID 67184N-bromobutanimide

HCID 69114725(1-Cyanocyclopropyl)-2-hydroxymethyl-cyclohexane-carboxamide

Product 1

HCID 69115024(1-Cyanocyclopropyl)-2-bromomethylcyclohexanecarboxamide

Sources & evidence

ORD record: ord-560b322002ca4f24981e5d3ef5552f2c
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (3/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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