Dimethyl Sulfoxide → Tert-butyl 4-(5-methyl-7-oxo-5,6-dihydrocyclopenta[d]pyrimidin-4-yl)piperazine-1-carboxylate

HRID 674346Notes

Reaction equation

HRID 674346 reaction equation
[CH3:39][CH2:40][O:41][C:42]([CH3:43])=[O:44].[CH3:7][S:8]([CH3:9])=[O:10].[Cl:1][C:2]([C:3]([Cl:4])=[O:5])=[O:6].[Cl:36][CH2:37][Cl:38].[OH2:35].[OH:11][CH:12]1[CH2:13][CH:14]([CH3:34])[c:15]2[c:16]1[n:17][cH:18][n:19][c:20]2[N:21]1[CH2:22][CH2:23][N:24]([C:27](=[O:28])[O:29][C:30]([CH3:31])([CH3:32])[CH3:33])[CH2:25][CH2:26]1>>[O:11]=[C:12]1[CH2:13][CH:14]([CH3:34])[c:15]2[c:16]1[n:17][cH:18][n:19][c:20]2[N:21]1[CH2:22][CH2:23][N:24]([C:27](=[O:28])[O:29][C:30]([CH3:31])([CH3:32])[CH3:33])[CH2:25][CH2:26]1

Participants

7

Reactant 6

HCID 679Dimethyl SulfoxideHCID 962WaterHCID 6344DichloromethaneHCID 8857Ethyl AcetateHCID 65578Oxalyl chlorideHCID 66618169tert-butyl 4-[(5R,7R)-7-hydroxy-5-methyl-5H,6H,7H-cyclopenta[d]pyrimidin-4-yl]piperazine-1-carboxylate

Product 1

HCID 66618145Tert-butyl 4-(5-methyl-7-oxo-5,6-dihydrocyclopenta[d]pyrimidin-4-yl)piperazine-1-carboxylate

Sources & evidence

ORD record
ord-b9e81d7624dc4bf69fa40b370e738f84
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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