Dichloromethane → 5-(2,4-dichlorophenyl)-N-(4-ethoxypyrrolidin-3-yl)-3,6-diethylpyrazin-2-amine

HRID 675178Notes

Reaction equation

HRID 675178 reaction equation
[CH2:38]([N:39]([CH2:40][CH3:41])[CH2:42][CH3:43])[CH3:44].[CH2:45]([SiH:46]([CH2:47][CH3:48])[CH2:49][CH3:50])[CH3:51].[Cl:1][c:2]1[c:3](-[c:9]2[n:10][c:11]([CH2:36][CH3:37])[c:12]([NH:17][CH:18]3[CH2:19][N:20]([C:26]([O:27][CH2:28][c:29]4[cH:30][cH:31][cH:32][cH:33][cH:34]4)=[O:35])[CH2:21][CH:22]3[O:23][CH2:24][CH3:25])[n:13][c:14]2[CH2:15][CH3:16])[cH:4][cH:5][c:6]([Cl:8])[cH:7]1.[Cl:52][CH2:53][Cl:54].[Pd:55]([Cl:56])[Cl:57]>>[Cl:1][c:2]1[c:3](-[c:9]2[n:10][c:11]([CH2:36][CH3:37])[c:12]([NH:17][CH:18]3[CH2:19][NH:20][CH2:21][CH:22]3[O:23][CH2:24][CH3:25])[n:13][c:14]2[CH2:15][CH3:16])[cH:4][cH:5][c:6]([Cl:8])[cH:7]1

Participants

6

Reactant 5

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 12052TriethylsilaneHCID 24290Palladium ChlorideHCID 22147242HCID 22147242, compound

Product 1

HCID 101944255-(2,4-dichlorophenyl)-N-(4-ethoxypyrrolidin-3-yl)-3,6-diethylpyrazin-2-amine

Sources & evidence

ORD record
ord-ab21ce7ba67d49ad97632434206309c2
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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