Diethyl Ether → 1-Benzyl-3-(3-trifluoromethyl-phenyl)-piperidine-3-ol
Reaction equation
[Br:3][c:4]1[cH:5][c:6]([C:10]([F:11])([F:12])[F:13])[cH:7][cH:8][cH:9]1.[CH2:14]([c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1)[N:21]1[CH2:22][C:23](=[O:27])[CH2:24][CH2:25][CH2:26]1.[CH2:28]([O:29][CH2:30][CH3:31])[CH3:32].[I:2].[Mg:1]>>[c:4]1([C:23]2([OH:27])[CH2:22][N:21]([CH2:14][c:15]3[cH:16][cH:17][cH:18][cH:19][cH:20]3)[CH2:26][CH2:25][CH2:24]2)[cH:5][c:6]([C:10]([F:11])([F:12])[F:13])[cH:7][cH:8][cH:9]1Participants
6
Sources & evidence
- ORD record
- ord-63e02edea89f498b9f3f7f8c4217831a
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (3/10)
Reaction notes
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