Dichloromethane → (3aRS,4RS,6SR,7aSR)-4-(2-methoxyphenyl)-2-[(2-methoxyphenyl)acetyl]-6-tosylmethylperhydroisoindol-4-ol

HRID 676472Notes

Reaction equation

HRID 676472 reaction equation
[CH3:43][CH2:44][N:45]([CH2:46][CH3:47])[CH2:48][CH3:49].[Cl:50][CH2:51][Cl:52].[OH:12][CH2:13][CH:14]1[CH2:15][C:16]([OH:34])([c:35]2[c:36]([O:41][CH3:42])[cH:37][cH:38][cH:39][cH:40]2)[CH:17]2[CH2:18][N:19]([C:23]([CH2:24][c:25]3[c:26]([O:31][CH3:32])[cH:27][cH:28][cH:29][cH:30]3)=[O:33])[CH2:20][CH:21]2[CH2:22]1.[c:1]1([CH3:11])[cH:2][cH:3][c:4]([S:7](=[O:8])(=[O:9])[Cl:10])[cH:5][cH:6]1>>[c:1]1([CH3:11])[cH:2][cH:3][c:4]([S:7](=[O:8])(=[O:9])[CH2:13][CH:14]2[CH2:15][C:16]([OH:34])([c:35]3[c:36]([O:41][CH3:42])[cH:37][cH:38][cH:39][cH:40]3)[CH:17]3[CH2:18][N:19]([C:23]([CH2:24][c:25]4[c:26]([O:31][CH3:32])[cH:27][cH:28][cH:29][cH:30]4)=[O:33])[CH2:20][CH:21]3[CH2:22]2)[cH:5][cH:6]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 73974-Toluenesulfonyl chlorideHCID 8471TriethylamineHCID 67714143(3aRS,4RS,6SR,7aSR)-6-hydroxymethyl-4-(2-methoxyphenyl)-2-[(2-methoxyphenyl)acetyl]perhydroisoindol-4-ol

Product 1

HCID 86752423(3aRS,4RS,6SR,7aSR)-4-(2-methoxyphenyl)-2-[(2-methoxyphenyl)acetyl]-6-tosylmethylperhydroisoindol-4-ol

Sources & evidence

ORD record
ord-50452d656cf84a94950eb02de8505d56
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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