Ethyl Acetoacetate → 4-dodecoxyethylaminoethyl-7-methyl-3,6-dihydro-2H-1,4-diazepin-5-one

HRID 67664Notes

Reaction equation

[CH2:1]([O:13][CH2:14][CH2:15][NH:16][CH2:17][CH2:18][NH:19][CH2:20][CH2:21][NH2:22])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12].[C:23](OCC)(=[O:28])[CH2:24][C:25]([CH3:27])=O>>[CH2:1]([O:13][CH2:14][CH2:15][NH:16][CH2:17][CH2:18][N:19]1[C:23](=[O:28])[CH2:24][C:25]([CH3:27])=[N:22][CH2:21][CH2:20]1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12]

Participants

Reactant 2

HCID 8868Ethyl Acetoacetate

HCID 20527003N-dodecoxyethyldiethylenetriamine

Product 1

HCID 705483164-dodecoxyethylaminoethyl-7-methyl-3,6-dihydro-2H-1,4-diazepin-5-one

Procedure

Into an apparatus similar to that in Example 1, were charged 315.1 g (1 mole) of N-dodecoxyethyldiethylenetriamine and 130.1 g (1 mole) of ethyl acetoacetate at 150° to 160° C., 18 g of water and 46 g of ethanol were distilled off to obtain 4-dodecoxyethylaminoethyl-7-methyl-3,6-dihydro-2H-1,4-diazepin-5-one.

Workup

distillation18 g of water and 46 g of ethanol were distilled off

Sources & evidence

ORD record: ord-338dd568fcad46b7afde5f9a9ad1621f
Source dataset: uspto-grants-1982_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04346087

Reaction notes

Loading…