Hydrochloric Acid → (Z)-tert-butyl 3-(3-oxopropyl)-6-(8-(3-((2-(trimethylsilyl)ethoxy)methyl)benzo[d]thiazol-2(3H)-ylidenecarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)picolinate

HRID 677840Notes

Reaction equation

[CH2:52]1[O:53][CH2:54][CH2:55][CH2:56]1.[ClH:51].[O:1]1[CH:2]([CH2:6][CH2:7][c:8]2[c:9]([C:44](=[O:45])[O:46][C:47]([CH3:48])([CH3:49])[CH3:50])[n:10][c:11]([N:14]3[CH2:15][c:16]4[c:17]([C:24]([N:25]=[c:26]5[s:27][c:28]6[c:29]([n:30]5[CH2:31][O:32][CH2:33][CH2:34][Si:35]([CH3:36])([CH3:37])[CH3:38])[cH:39][cH:40][cH:41][cH:42]6)=[O:43])[cH:18][cH:19][cH:20][c:21]4[CH2:22][CH2:23]3)[cH:12][cH:13]2)[O:5][CH2:4][CH2:3]1>>[O:1]=[CH:2][CH2:6][CH2:7][c:8]1[c:9]([C:44](=[O:45])[O:46][C:47]([CH3:48])([CH3:49])[CH3:50])[n:10][c:11]([N:14]2[CH2:15][c:16]3[c:17]([C:24]([N:25]=[c:26]4[s:27][c:28]5[c:29]([n:30]4[CH2:31][O:32][CH2:33][CH2:34][Si:35]([CH3:36])([CH3:37])[CH3:38])[cH:39][cH:40][cH:41][cH:42]5)=[O:43])[cH:18][cH:19][cH:20][c:21]3[CH2:22][CH2:23]2)[cH:12][cH:13]1

Participants

Reactant 3

HCID 313Hydrochloric Acid

HCID 8028Tetrahydrofuran

HCID 59447627(Z)-tert-butyl 3-(2-(1,3-dioxolan-2-yl)ethyl)-6-(8-(3-((2-(trimethylsilyl)ethoxy)methyl)benzo[d]thiazol-2(3H)-ylidenecarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)picolinate

Product 1

HCID 59447622(Z)-tert-butyl 3-(3-oxopropyl)-6-(8-(3-((2-(trimethylsilyl)ethoxy)methyl)benzo[d]thiazol-2(3H)-ylidenecarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)picolinate

Sources & evidence

ORD record: ord-dd6e18daea374512a87dcdf05821f39b
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (3/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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