Methanol → 3,5-Dimethyl-4-[8-(2,3,4-trifluoro-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino]-piperidine-1-carboxylic acid tert-butyl ester
Reaction equation
[CH2:55]1[O:56][CH2:57][CH2:58][CH2:59]1.[CH3:28][CH2:29][N:30]([CH2:31][CH3:32])[CH2:33][CH3:34].[CH3:35][P:36]([CH3:37])[CH3:38].[CH3:39][CH:40]1[CH2:41][N:42]([C:48](=[O:49])[O:50][C:51]([CH3:52])([CH3:53])[CH3:54])[CH2:43][CH:44]([CH3:47])[C:45]1=[O:46].[CH3:60][OH:61].[Cl:20][C:21]([C:22]([Cl:23])([Cl:24])[Cl:25])([Cl:26])[Cl:27].[F:1][c:2]1[c:3](-[c:10]2[c:11]3[n:12]([cH:13][cH:14][cH:15]2)[n:16][c:17]([NH2:19])[n:18]3)[cH:4][cH:5][c:6]([F:9])[c:7]1[F:8].[OH2:62]>>[F:1][c:2]1[c:3](-[c:10]2[c:11]3[n:12]([cH:13][cH:14][cH:15]2)[n:16][c:17]([NH:19][CH:45]2[CH:40]([CH3:39])[CH2:41][N:42]([C:48](=[O:49])[O:50][C:51]([CH3:52])([CH3:53])[CH3:54])[CH2:43][CH:44]2[CH3:47])[n:18]3)[cH:4][cH:5][c:6]([F:9])[c:7]1[F:8]Participants
9
Reactant 8
Product 1
Sources & evidence
- ORD record
- ord-f8ec8898efac49f3aa1a10d609814d29
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (3/10)
Reaction notes
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