反应详情

A mixture of 2-iodotoluene (6.54 g), N-(2-propynyl)piperidine (3.69 g), dichlorobis(triphenylphosphino)palladium(II) (0.05 g) and copper(I) iodide (0.1 g) in dry diethylamine (50 ml) was heated under reflux for 5 hours. The solvent was removed under reduced pressure and the residue was taken up in diethyl ether and washed with water. The organic phase was dried over magnesium sulfate and concentrated completely under reduced pressure. Distillation of the residue under reduced pressure gave 3.98 g of an oil of boiling point 96–98° C./0.08 mm Hg.

1. temperaturewas heated
2. temperatureunder reflux for 5 hours
3. customThe solvent was removed under reduced pressure
4. washwashed with water
5. dry with materialThe organic phase was dried over magnesium sulfate
6. concentrationconcentrated completely under reduced pressure
7. distillationDistillation of the residue under reduced pressure