反应详情

With stirring, a solution of 2-propynyl chloride (40.31 g) in dry methanol (50 ml) was added dropwise to a solution of piperidine (92.14 g) in dry methanol (100 ml). The mixture was stirred at 25° C. for 3 hours and then filtered. The filtrate was concentrated under reduced pressure and the residue was distilled (boiling point: 163–165° C./atmospheric pressure).

1. stirringThe mixture was stirred at 25° C. for 3 hours
2. filtrationfiltered
3. concentrationThe filtrate was concentrated under reduced pressure
4. distillationthe residue was distilled (boiling point: 163–165° C./atmospheric pressure)