Dimethylformamide → 1-(1,3-benzodioxol-5-yl)-N-[5-[(tert-butylsulfinylamino)-(2-chlorophenyl)methyl]-4-methyl-1,3-thiazol-2-yl]cyclopropane-1-carboxamide

HRID 679089Notes

Reaction equation

HRID 679089 reaction equation
[CH3:42][CH2:43][N:44]([CH2:45][CH3:46])[CH2:47][CH3:48].[Cl:49][CH2:50][Cl:51].[NH2:20][c:21]1[s:22][c:23]([CH:27]([NH:28][S:29](=[O:30])[C:31]([CH3:32])([CH3:33])[CH3:34])[c:35]2[c:36]([Cl:41])[cH:37][cH:38][cH:39][cH:40]2)[c:24]([CH3:26])[n:25]1.[O:1]1[CH2:2][O:3][c:4]2[c:5]1[cH:6][cH:7][c:8]([C:10]1([C:13](=[O:14])[OH:15])[CH2:11][CH2:12]1)[cH:9]2.[O:52]=[CH:53][N:54]([CH3:55])[CH3:56].[S:16]([Cl:17])([Cl:18])=[O:19]>>[O:1]1[CH2:2][O:3][c:4]2[c:5]1[cH:6][cH:7][c:8]([C:10]1([C:13](=[O:15])[NH:20][c:21]3[s:22][c:23]([CH:27]([NH:28][S:29](=[O:30])[C:31]([CH3:32])([CH3:33])[CH3:34])[c:35]4[c:36]([Cl:41])[cH:37][cH:38][cH:39][cH:40]4)[c:24]([CH3:26])[n:25]3)[CH2:11][CH2:12]1)[cH:9]2

Participants

7

Reactant 6

HCID 6228DimethylformamideHCID 6344DichloromethaneHCID 8471TriethylamineHCID 24386Thionyl ChlorideHCID 143496081-(1,3-Dioxaindan-5-yl)cyclopropane-1-carboxylic acidHCID 76672767HCID 76672767, compound

Product 1

HCID 766727341-(1,3-benzodioxol-5-yl)-N-[5-[(tert-butylsulfinylamino)-(2-chlorophenyl)methyl]-4-methyl-1,3-thiazol-2-yl]cyclopropane-1-carboxamide

Sources & evidence

ORD record
ord-1119a3f5399b4481b6fc46fe57b3a5d1
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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